head to head
Neither is simply harder - they are hard in different places. Cayne demands more variance; Portal 2 demands more execution.

Optimization · Pure Optimization
Solving fixed grim puzzles to escape a facility, dexterity-free.

Optimization · Pure Optimization
A first-person puzzle game where seeing the solution is the whole skill.
Cayne leans Optimization (Pure Optimization); Portal 2 leans Optimization (Pure Optimization).
Portal 2 leans clearly harder on execution.
Cayne
Isometric point-and-click, no dexterity
Portal 2
Portal placement requires some precision but timing is lenient.
Same score on reads - which means the number cannot separate them. The difference is in what each one asks of you.
Cayne
No adaptive threat in the facility
Portal 2
No opponent; puzzles are static.
Cayne leans clearly harder on variance.
Cayne
Story horrors are hidden until uncovered, then static
Portal 2
Puzzles are deterministic with no randomness.
Portal 2 leans clearly harder on optimization.
Cayne
Solving fixed environmental puzzles drives all progress
Portal 2
Solving the puzzle's logic IS the entire game.
A matching score does not mean a matching test. Two games can both sit at 10 on execution and demand completely different things of you - which is why the reasoning above matters more than the number beside it.