head to head
Neither is meaningfully harder - they pose close to the same test. The widest gap is optimization, and it is a single point.

Execution · Pure Mechanics
Comic-panel beat 'em up notorious for punishing health drain and tough fights.

Execution · Pure Mechanics
High-tempo brawler execution against fixed crowd choreography.
Comix Zone leans Execution (Pure Mechanics); Midnight Fight Express leans Execution (Pure Mechanics).
Same score on execution - which means the number cannot separate them. The difference is in what each one asks of you.
Comix Zone
Brutal one-life brawling demands clean play
Midnight Fight Express
Crowd-control timing, counters and weapon juggling carry levels
Same score on reads - which means the number cannot separate them. The difference is in what each one asks of you.
Comix Zone
Enemies follow fixed attack scripts
Midnight Fight Express
Thugs attack on scripted cues
Same score on variance - which means the number cannot separate them. The difference is in what each one asks of you.
Comix Zone
Everything is placed and scripted
Midnight Fight Express
Fixed level setups every attempt
Comix Zone leans a little harder on optimization, though the gap is small.
Comix Zone
Panel routes and item use are memorizable
Midnight Fight Express
Skill unlocks and route knowledge polish scores
A matching score does not mean a matching test. Two games can both sit at 10 on execution and demand completely different things of you - which is why the reasoning above matters more than the number beside it.