head to head
Fallout: New Vegas asks more than Defense Grid 2, and the gap is execution.

Optimization · Pure Optimization
A classic maze-building tower defense won almost entirely through optimal layouts.

Optimization · Pure Optimization
A faction-driven RPG-shooter where build and route planning shape every ending.
Defense Grid 2 leans Optimization (Pure Optimization); Fallout: New Vegas leans Optimization (Pure Optimization).
Fallout: New Vegas leans clearly harder on execution.
Defense Grid 2
Occasional orbital-ability timing, otherwise hands-off
Fallout: New Vegas
Shooter inputs with VATS assist
Fallout: New Vegas leans a little harder on reads, though the gap is small.
Defense Grid 2
Fixed alien wave scripts, nothing adapts
Fallout: New Vegas
Scripted factions and enemies
Fallout: New Vegas leans a little harder on variance, though the gap is small.
Defense Grid 2
Spawn schedules are deterministic and previewable
Fallout: New Vegas
Some loot and crit RNG
Defense Grid 2 leans a little harder on optimization, though the gap is small.
Defense Grid 2
Maze routing and tower economy are a solvable puzzle
Fallout: New Vegas
Faction routing, perks, builds heavily rewarded
A matching score does not mean a matching test. Two games can both sit at 10 on execution and demand completely different things of you - which is why the reasoning above matters more than the number beside it.