head to head
Diablo IIIvsPathologic 2
Diablo III leans Optimization (Pure Optimization); Pathologic 2 leans Optimization (Systems & Chaos).
Diablo IIIPathologic 2
Axis by axis
Execution4 vs 4
Even - both lean on execution about the same.
Reads1 vs 1
Even - both lean on reads about the same.
Variance5 vs 6
Pathologic 2 leans harder on variance: Hunger, infection, and supplies fluctuate.
Optimization9 vs 8
Diablo III leans harder on optimization: Set bonuses and paragon levelling are almost entirely solvable
Two games can score the same on an axis and still test it in very different ways - read each rationale, not just the number.

