head to head
Dr. Luigi asks more than Grand Theft Auto: San Andreas, and the gap is execution.

Execution · Practiced Mastery
Falling-pill placement speed against virus layouts, with light versus pressure.

Optimization · Practiced Mastery
A sprawling open-world crime epic with RPG-style character stats across a whole state.
Dr. Luigi leans Execution (Practiced Mastery); Grand Theft Auto: San Andreas leans Optimization (Practiced Mastery).
Dr. Luigi leans clearly harder on execution.
Dr. Luigi
Fast pill placement under pressure decides clears
Grand Theft Auto: San Andreas
Flying school and drive-bys need decent hands
Dr. Luigi leans clearly harder on reads.
Dr. Luigi
Versus mode adds mild tempo prediction against humans
Grand Theft Auto: San Andreas
Gang AI is scripted, never adaptive
Dr. Luigi leans a little harder on variance, though the gap is small.
Dr. Luigi
Pill colours and virus layouts vary each round
Grand Theft Auto: San Andreas
Territory wars and traffic add light randomness
Grand Theft Auto: San Andreas leans a little harder on optimization, though the gap is small.
Dr. Luigi
L-pill placement patterns and combo setups are learnable
Grand Theft Auto: San Andreas
Stats, gym, weapon skill, and routes reward systematic play
A matching score does not mean a matching test. Two games can both sit at 10 on execution and demand completely different things of you - which is why the reasoning above matters more than the number beside it.