head to head
Dr. Mario asks more than Grand Theft Auto: San Andreas, and the gap is execution.

Execution · Practiced Mastery
Rapid capsule placement against a clock, with planning for chains under random pill draws.

Optimization · Practiced Mastery
A sprawling open-world crime epic with RPG-style character stats across a whole state.
Dr. Mario leans Execution (Practiced Mastery); Grand Theft Auto: San Andreas leans Optimization (Practiced Mastery).
Dr. Mario leans clearly harder on execution.
Dr. Mario
Fast capsule placement under rising speed decides clears
Grand Theft Auto: San Andreas
Flying school and drive-bys need decent hands
Dr. Mario leans a little harder on reads, though the gap is small.
Dr. Mario
Versus mode exists but garbage exchange rewards speed, not prediction
Grand Theft Auto: San Andreas
Gang AI is scripted, never adaptive
Dr. Mario leans a little harder on variance, though the gap is small.
Dr. Mario
Random pill colors against fixed virus layouts, quickly bounded
Grand Theft Auto: San Andreas
Territory wars and traffic add light randomness
Grand Theft Auto: San Andreas leans a little harder on optimization, though the gap is small.
Dr. Mario
Chain setups and virus-clearing order follow known patterns
Grand Theft Auto: San Andreas
Stats, gym, weapon skill, and routes reward systematic play
A matching score does not mean a matching test. Two games can both sit at 10 on execution and demand completely different things of you - which is why the reasoning above matters more than the number beside it.