head to head
Neither is meaningfully harder - they pose close to the same test. The widest gap is reads, and it is a single point.

Optimization · Pure Optimization
A VATS-heavy wasteland RPG won by perk and build optimization.

Optimization · Pure Optimization
A 2000 action RPG spanning centuries of a crusader-turned-vampire's redemption.
Fallout 3 leans Optimization (Pure Optimization); Vampire: The Masquerade - Redemption leans Optimization (Pure Optimization).
Same score on execution - which means the number cannot separate them. The difference is in what each one asks of you.
Fallout 3
VATS-leaning combat, low aim demand
Vampire: The Masquerade - Redemption
Click-driven real-time combat needs little dexterity
Fallout 3 leans a little harder on reads, though the gap is small.
Fallout 3
Scripted enemies
Vampire: The Masquerade - Redemption
Enemy AI is simple and scripted
Same score on variance - which means the number cannot separate them. The difference is in what each one asks of you.
Fallout 3
Loot rolls, SPECIAL checks
Vampire: The Masquerade - Redemption
Loot rolls and unknown dungeons on first pass
Fallout 3 leans a little harder on optimization, though the gap is small.
Fallout 3
Perk and build planning carries the run
Vampire: The Masquerade - Redemption
Discipline builds, party gear, and blood economy
A matching score does not mean a matching test. Two games can both sit at 10 on execution and demand completely different things of you - which is why the reasoning above matters more than the number beside it.