head to head
Neither is simply harder - they are hard in different places. Fallout: New Vegas demands more execution; Master of Orion (2016) demands more variance.

Optimization · Pure Optimization
A faction-driven RPG-shooter where build and route planning shape every ending.

Optimization · Pure Optimization
Optimizing custom race design and tech priorities across a randomly generated galaxy.
Fallout: New Vegas leans Optimization (Pure Optimization); Master of Orion (2016) leans Optimization (Pure Optimization).
Fallout: New Vegas leans clearly harder on execution.
Fallout: New Vegas
Shooter inputs with VATS assist
Master of Orion (2016)
Turn-based menus; no physical demands at all
Master of Orion (2016) leans a little harder on reads, though the gap is small.
Fallout: New Vegas
Scripted factions and enemies
Master of Orion (2016)
AI races follow defined personalities without adapting to your play
Master of Orion (2016) leans clearly harder on variance.
Fallout: New Vegas
Some loot and crit RNG
Master of Orion (2016)
Random galaxy generation and diplomatic outcomes add hidden elements
Master of Orion (2016) leans a little harder on optimization, though the gap is small.
Fallout: New Vegas
Faction routing, perks, builds heavily rewarded
Master of Orion (2016)
Race design, tech priorities, and fleet composition are the solvable core
A matching score does not mean a matching test. Two games can both sit at 10 on execution and demand completely different things of you - which is why the reasoning above matters more than the number beside it.