head to head
Neither is harder. They score identically on all four axes, so the difference between them is in kind, not degree.

Optimization · Pure Optimization
Optimizing game development decisions around hidden genre-topic match formulas to maximize review scores and revenue.

Optimization · Pure Optimization
Comic hospital tycoon optimized by room layouts and staffing.
Game Dev Tycoon leans Optimization (Pure Optimization); Two Point Hospital leans Optimization (Pure Optimization).
Same score on execution - which means the number cannot separate them. The difference is in what each one asks of you.
Game Dev Tycoon
All choices are menu clicks with no physical ceiling
Two Point Hospital
no reflex
Same score on reads - which means the number cannot separate them. The difference is in what each one asks of you.
Game Dev Tycoon
No adaptive human competitor to model
Two Point Hospital
no adversary
Same score on variance - which means the number cannot separate them. The difference is in what each one asks of you.
Game Dev Tycoon
Review scores and trend timing have meaningful randomness
Two Point Hospital
patient illness mix
Same score on optimization - which means the number cannot separate them. The difference is in what each one asks of you.
Game Dev Tycoon
Genre-topic-audience matching and R&D investment are learnable formulas
Two Point Hospital
room layouts, staffing, training
A matching score does not mean a matching test. Two games can both sit at 10 on execution and demand completely different things of you - which is why the reasoning above matters more than the number beside it.