head to head
Neither is simply harder - they are hard in different places. Grand Theft Auto: San Andreas demands more optimization; Guns, Gore and Cannoli 2 demands more execution.

Optimization · Practiced Mastery
A sprawling open-world crime epic with RPG-style character stats across a whole state.

Execution · Practiced Mastery
A cartoonish 2D run-and-gun shooter set amid a mob war.
Grand Theft Auto: San Andreas leans Optimization (Practiced Mastery); Guns, Gore and Cannoli 2 leans Execution (Practiced Mastery).
Guns, Gore and Cannoli 2 leans clearly harder on execution.
Grand Theft Auto: San Andreas
Flying school and drive-bys need decent hands
Guns, Gore and Cannoli 2
run-and-gun aiming and dodging skill
Same score on reads - which means the number cannot separate them. The difference is in what each one asks of you.
Grand Theft Auto: San Andreas
Gang AI is scripted, never adaptive
Guns, Gore and Cannoli 2
scripted enemy waves, not adaptive
Same score on variance - which means the number cannot separate them. The difference is in what each one asks of you.
Grand Theft Auto: San Andreas
Territory wars and traffic add light randomness
Guns, Gore and Cannoli 2
some enemy spawn randomness
Grand Theft Auto: San Andreas leans clearly harder on optimization.
Grand Theft Auto: San Andreas
Stats, gym, weapon skill, and routes reward systematic play
Guns, Gore and Cannoli 2
weapon and route optimization
A matching score does not mean a matching test. Two games can both sit at 10 on execution and demand completely different things of you - which is why the reasoning above matters more than the number beside it.