head to head
Neither is simply harder - they are hard in different places. Grand Theft Auto: San Andreas demands more optimization; Poison Control demands more execution.

Optimization · Practiced Mastery
A sprawling open-world crime epic with RPG-style character stats across a whole state.

Execution · Practiced Mastery
A stylish anime bullet-hell shooter about cleaning up poison.
Grand Theft Auto: San Andreas leans Optimization (Practiced Mastery); Poison Control leans Execution (Practiced Mastery).
Poison Control leans clearly harder on execution.
Grand Theft Auto: San Andreas
Flying school and drive-bys need decent hands
Poison Control
Bullet-hell dodging and aiming precision
Poison Control leans a little harder on reads, though the gap is small.
Grand Theft Auto: San Andreas
Gang AI is scripted, never adaptive
Poison Control
Fixed boss patterns, no adaptation
Same score on variance - which means the number cannot separate them. The difference is in what each one asks of you.
Grand Theft Auto: San Andreas
Territory wars and traffic add light randomness
Poison Control
Some enemy spawn randomness
Grand Theft Auto: San Andreas leans clearly harder on optimization.
Grand Theft Auto: San Andreas
Stats, gym, weapon skill, and routes reward systematic play
Poison Control
Build/route optimization secondary
A matching score does not mean a matching test. Two games can both sit at 10 on execution and demand completely different things of you - which is why the reasoning above matters more than the number beside it.