head to head
Neither is simply harder - they are hard in different places. Grand Theft Auto: San Andreas demands more variance; Sekiro: Shadows Die Twice demands more execution.

Optimization · Practiced Mastery
A sprawling open-world crime epic with RPG-style character stats across a whole state.

Execution · Practiced Mastery
A rhythm-parry action game about reading scripted tells with frame-tight timing.
Grand Theft Auto: San Andreas leans Optimization (Practiced Mastery); Sekiro: Shadows Die Twice leans Execution (Practiced Mastery).
Sekiro: Shadows Die Twice leans clearly harder on execution.
Grand Theft Auto: San Andreas
Flying school and drive-bys need decent hands
Sekiro: Shadows Die Twice
Frame-perfect parries are the entire combat system.
Sekiro: Shadows Die Twice leans clearly harder on reads.
Grand Theft Auto: San Andreas
Gang AI is scripted, never adaptive
Sekiro: Shadows Die Twice
Mikiri and perilous tells are scripted, not adaptive.
Grand Theft Auto: San Andreas leans clearly harder on variance.
Grand Theft Auto: San Andreas
Territory wars and traffic add light randomness
Sekiro: Shadows Die Twice
Almost no randomness; encounters are deterministic.
Sekiro: Shadows Die Twice leans a little harder on optimization, though the gap is small.
Grand Theft Auto: San Andreas
Stats, gym, weapon skill, and routes reward systematic play
Sekiro: Shadows Die Twice
Boss decks and prosthetic choices are fully learnable.
A matching score does not mean a matching test. Two games can both sit at 10 on execution and demand completely different things of you - which is why the reasoning above matters more than the number beside it.