head to head
Grand Theft Auto: San Andreas asks more than Uncharted 3: Drake's Deception, and the gap is optimization.

Optimization · Practiced Mastery
A sprawling open-world crime epic with RPG-style character stats across a whole state.

Execution · Practiced Mastery
A cinematic desert-bound adventure of shootouts, brawls, and sinking-ship set pieces.
Grand Theft Auto: San Andreas leans Optimization (Practiced Mastery); Uncharted 3: Drake's Deception leans Execution (Practiced Mastery).
Uncharted 3: Drake's Deception leans a little harder on execution, though the gap is small.
Grand Theft Auto: San Andreas
Flying school and drive-bys need decent hands
Uncharted 3: Drake's Deception
Gunfights, melee, and chases need steady hands
Uncharted 3: Drake's Deception leans a little harder on reads, though the gap is small.
Grand Theft Auto: San Andreas
Gang AI is scripted, never adaptive
Uncharted 3: Drake's Deception
Scripted enemies; multiplayer adds a trace
Grand Theft Auto: San Andreas leans a little harder on variance, though the gap is small.
Grand Theft Auto: San Andreas
Territory wars and traffic add light randomness
Uncharted 3: Drake's Deception
Linear authored adventure
Grand Theft Auto: San Andreas leans clearly harder on optimization.
Grand Theft Auto: San Andreas
Stats, gym, weapon skill, and routes reward systematic play
Uncharted 3: Drake's Deception
Learning encounters and routes solves the campaign
A matching score does not mean a matching test. Two games can both sit at 10 on execution and demand completely different things of you - which is why the reasoning above matters more than the number beside it.