head to head
Grand Theft Auto: San Andreas asks more than Uncharted: Drake's Fortune, and the gap is optimization.

Optimization · Practiced Mastery
A sprawling open-world crime epic with RPG-style character stats across a whole state.

Execution · Practiced Mastery
The first cinematic treasure-hunting adventure of cover shootouts and cliffside climbing.
Grand Theft Auto: San Andreas leans Optimization (Practiced Mastery); Uncharted: Drake's Fortune leans Execution (Practiced Mastery).
Uncharted: Drake's Fortune leans a little harder on execution, though the gap is small.
Grand Theft Auto: San Andreas
Flying school and drive-bys need decent hands
Uncharted: Drake's Fortune
Cover gunfights and climbing timing
Same score on reads - which means the number cannot separate them. The difference is in what each one asks of you.
Grand Theft Auto: San Andreas
Gang AI is scripted, never adaptive
Uncharted: Drake's Fortune
Mercenary AI is scripted waves
Grand Theft Auto: San Andreas leans a little harder on variance, though the gap is small.
Grand Theft Auto: San Andreas
Territory wars and traffic add light randomness
Uncharted: Drake's Fortune
Fully authored set pieces
Grand Theft Auto: San Andreas leans clearly harder on optimization.
Grand Theft Auto: San Andreas
Stats, gym, weapon skill, and routes reward systematic play
Uncharted: Drake's Fortune
Encounter layouts and weapon choices are learnable
A matching score does not mean a matching test. Two games can both sit at 10 on execution and demand completely different things of you - which is why the reasoning above matters more than the number beside it.