head to head
Neither is simply harder - they are hard in different places. How to Survive demands more variance; Portal 2 demands more optimization.

Optimization · Pure Optimization
Crafting-tree planning and needs management under light zombie pressure.

Optimization · Pure Optimization
A first-person puzzle game where seeing the solution is the whole skill.
How to Survive leans Optimization (Pure Optimization); Portal 2 leans Optimization (Pure Optimization).
How to Survive leans a little harder on execution, though the gap is small.
How to Survive
Twin-stick zombie kiting needs modest aim
Portal 2
Portal placement requires some precision but timing is lenient.
Same score on reads - which means the number cannot separate them. The difference is in what each one asks of you.
How to Survive
Zombies are mindless scripted pressure
Portal 2
No opponent; puzzles are static.
How to Survive leans clearly harder on variance.
How to Survive
Scavenged materials and island layouts are unknown until explored
Portal 2
Puzzles are deterministic with no randomness.
Portal 2 leans clearly harder on optimization.
How to Survive
Crafting trees and needs management decide survival
Portal 2
Solving the puzzle's logic IS the entire game.
A matching score does not mean a matching test. Two games can both sit at 10 on execution and demand completely different things of you - which is why the reasoning above matters more than the number beside it.