head to head
Neither is simply harder - they are hard in different places. Mario & Luigi: Paper Jam demands more variance; Portal 2 demands more optimization.

Optimization · Pure Optimization
A timing-flavoured turn-based RPG where party builds and learned attack patterns decide fights.

Optimization · Pure Optimization
A first-person puzzle game where seeing the solution is the whole skill.
Mario & Luigi: Paper Jam leans Optimization (Pure Optimization); Portal 2 leans Optimization (Pure Optimization).
Mario & Luigi: Paper Jam leans a little harder on execution, though the gap is small.
Mario & Luigi: Paper Jam
Timed action commands reward but never gate progress
Portal 2
Portal placement requires some precision but timing is lenient.
Same score on reads - which means the number cannot separate them. The difference is in what each one asks of you.
Mario & Luigi: Paper Jam
Enemy attacks are scripted tells, not adaptive minds
Portal 2
No opponent; puzzles are static.
Mario & Luigi: Paper Jam leans clearly harder on variance.
Mario & Luigi: Paper Jam
Minor drop and damage rolls inside fixed encounters
Portal 2
Puzzles are deterministic with no randomness.
Portal 2 leans clearly harder on optimization.
Mario & Luigi: Paper Jam
Gear, badge and turn-order planning carries every fight
Portal 2
Solving the puzzle's logic IS the entire game.
A matching score does not mean a matching test. Two games can both sit at 10 on execution and demand completely different things of you - which is why the reasoning above matters more than the number beside it.