head to head
Neither is simply harder - they are hard in different places. Oxygen Not Included demands more variance; Portal 2 demands more execution.

Optimization · Pure Optimization
Engineering precise gas, liquid, and power circuits to keep a subterranean colony alive indefinitely.

Optimization · Pure Optimization
A first-person puzzle game where seeing the solution is the whole skill.
Oxygen Not Included leans Optimization (Pure Optimization); Portal 2 leans Optimization (Pure Optimization).
Portal 2 leans clearly harder on execution.
Oxygen Not Included
All inputs are build-order clicks; no twitch required
Portal 2
Portal placement requires some precision but timing is lenient.
Same score on reads - which means the number cannot separate them. The difference is in what each one asks of you.
Oxygen Not Included
No adversary of any kind exists in the colony
Portal 2
No opponent; puzzles are static.
Oxygen Not Included leans clearly harder on variance.
Oxygen Not Included
Asteroid seed and geyser placement carry meaningful but bounded randomness
Portal 2
Puzzles are deterministic with no randomness.
Oxygen Not Included leans a little harder on optimization, though the gap is small.
Oxygen Not Included
Gas, liquid, and power engineering are essentially a solvable engineering puzzle
Portal 2
Solving the puzzle's logic IS the entire game.
A matching score does not mean a matching test. Two games can both sit at 10 on execution and demand completely different things of you - which is why the reasoning above matters more than the number beside it.