head to head
Neither is simply harder - they are hard in different places. Portal 2 demands more optimization; Resident Evil 0 demands more variance.

Optimization · Pure Optimization
A first-person puzzle game where seeing the solution is the whole skill.

Optimization · Pure Optimization
Survival horror prequel built on swapping two characters with no item boxes.
Portal 2 leans Optimization (Pure Optimization); Resident Evil 0 leans Optimization (Pure Optimization).
Same score on execution - which means the number cannot separate them. The difference is in what each one asks of you.
Portal 2
Portal placement requires some precision but timing is lenient.
Resident Evil 0
Tank-control combat is modestly demanding
Same score on reads - which means the number cannot separate them. The difference is in what each one asks of you.
Portal 2
No opponent; puzzles are static.
Resident Evil 0
Enemies follow fixed behaviour
Resident Evil 0 leans clearly harder on variance.
Portal 2
Puzzles are deterministic with no randomness.
Resident Evil 0
Hidden layouts surprise until mapped
Portal 2 leans clearly harder on optimization.
Portal 2
Solving the puzzle's logic IS the entire game.
Resident Evil 0
Two-character item juggling makes routing the real game
A matching score does not mean a matching test. Two games can both sit at 10 on execution and demand completely different things of you - which is why the reasoning above matters more than the number beside it.