head to head
Neither is meaningfully harder - they pose close to the same test. The widest gap is execution, and it is a single point.

Optimization · Pure Optimization
A first-person puzzle game where seeing the solution is the whole skill.

Optimization · Pure Optimization
A hardcore programming-in-disguise puzzle where you wire atomic assembly lines to synthesize compounds.
Portal 2 leans Optimization (Pure Optimization); SpaceChem leans Optimization (Pure Optimization).
Portal 2 leans a little harder on execution, though the gap is small.
Portal 2
Portal placement requires some precision but timing is lenient.
SpaceChem
Drawing waldo paths requires no physical precision
Same score on reads - which means the number cannot separate them. The difference is in what each one asks of you.
Portal 2
No opponent; puzzles are static.
SpaceChem
No opponent; pure logic construction
Same score on variance - which means the number cannot separate them. The difference is in what each one asks of you.
Portal 2
Puzzles are deterministic with no randomness.
SpaceChem
All reactor inputs are deterministic and fixed
SpaceChem leans a little harder on optimization, though the gap is small.
Portal 2
Solving the puzzle's logic IS the entire game.
SpaceChem
Designing correct chemical pipelines that transform inputs to outputs exactly
A matching score does not mean a matching test. Two games can both sit at 10 on execution and demand completely different things of you - which is why the reasoning above matters more than the number beside it.