head to head
Neither is simply harder - they are hard in different places. Portal 2 demands more optimization; The Witcher demands more variance.

Optimization · Pure Optimization
A first-person puzzle game where seeing the solution is the whole skill.

Optimization · Pure Optimization
CD Projekt's first RPG, a dark fantasy of monster contracts and morally gray choices.
Portal 2 leans Optimization (Pure Optimization); The Witcher leans Optimization (Pure Optimization).
Same score on execution - which means the number cannot separate them. The difference is in what each one asks of you.
Portal 2
Portal placement requires some precision but timing is lenient.
The Witcher
Rhythm-click combat needs only loose timing
Same score on reads - which means the number cannot separate them. The difference is in what each one asks of you.
Portal 2
No opponent; puzzles are static.
The Witcher
Enemies follow fixed styles and weaknesses
The Witcher leans clearly harder on variance.
Portal 2
Puzzles are deterministic with no randomness.
The Witcher
Some unknown quest outcomes on first play
Portal 2 leans clearly harder on optimization.
Portal 2
Solving the puzzle's logic IS the entire game.
The Witcher
Signs, potions, and style matchups form the real game
A matching score does not mean a matching test. Two games can both sit at 10 on execution and demand completely different things of you - which is why the reasoning above matters more than the number beside it.