head to head
Neither is simply harder - they are hard in different places. Portal demands more execution; Runaway 3: A Twist of Fate demands more variance.

Optimization · Pure Optimization
The portal-gun puzzle game whose solutions are everything.

Optimization · Pure Optimization
Classic inventory-puzzle deduction through a fixed comedic story.
Portal leans Optimization (Pure Optimization); Runaway 3: A Twist of Fate leans Optimization (Pure Optimization).
Portal leans clearly harder on execution.
Portal
Portal placement timing modest.
Runaway 3: A Twist of Fate
Pointing and clicking is the only physical act
Same score on reads - which means the number cannot separate them. The difference is in what each one asks of you.
Portal
No adversary modeling player.
Runaway 3: A Twist of Fate
No opponent exists in a scripted story
Runaway 3: A Twist of Fate leans clearly harder on variance.
Portal
Deterministic chambers; no randomness.
Runaway 3: A Twist of Fate
Puzzle solutions are hidden only until found
Portal leans clearly harder on optimization.
Portal
Pure puzzle-solving optimization.
Runaway 3: A Twist of Fate
Inventory logic and dialogue puzzles have single fixed answers
A matching score does not mean a matching test. Two games can both sit at 10 on execution and demand completely different things of you - which is why the reasoning above matters more than the number beside it.