head to head
Neither is meaningfully harder - they pose close to the same test. The widest gap is execution, and it is a single point.

Execution · Twitch Chaos
Dodging under fire while leveraging deep item knowledge against run RNG.

Optimization · Practiced Mastery
A co-op third-person looter shooter where module build optimisation and drop variance define long-term progression.
The Binding of Isaac: Afterbirth+ leans Execution (Twitch Chaos); The First Descendant leans Optimization (Practiced Mastery).
The Binding of Isaac: Afterbirth+ leans a little harder on execution, though the gap is small.
The Binding of Isaac: Afterbirth+
Dodging bullet patterns while aiming tears is constant
The First Descendant
Colossus boss fights and intercept missions require dodge timing and aim
The First Descendant leans a little harder on reads, though the gap is small.
The Binding of Isaac: Afterbirth+
Enemies are random or scripted, never adaptive
The First Descendant
PvE co-op throughout with no meaningful adaptive opponent
The Binding of Isaac: Afterbirth+ leans a little harder on variance, though the gap is small.
The Binding of Isaac: Afterbirth+
Item pools, room layouts and pickups define each run
The First Descendant
Module drop RNG and Descendant unlock rates drive the grind
The First Descendant leans a little harder on optimization, though the gap is small.
The Binding of Isaac: Afterbirth+
Encyclopedic item synergy knowledge converts variance into wins
The First Descendant
Module builds and Descendant loadouts are extensively theory-crafted
A matching score does not mean a matching test. Two games can both sit at 10 on execution and demand completely different things of you - which is why the reasoning above matters more than the number beside it.