head to head
Neither is meaningfully harder - they pose close to the same test. The widest gap is execution, and it is a single point.

Execution · Twitch Chaos
Dodging under fire while leveraging deep item knowledge against run RNG.

Optimization · Practiced Mastery
Fantasy looter shooter with class hybrids.
The Binding of Isaac: Afterbirth+ leans Execution (Twitch Chaos); Tiny Tina's Wonderlands leans Optimization (Practiced Mastery).
The Binding of Isaac: Afterbirth+ leans a little harder on execution, though the gap is small.
The Binding of Isaac: Afterbirth+
Dodging bullet patterns while aiming tears is constant
Tiny Tina's Wonderlands
Gunplay similar to Borderlands 3
Tiny Tina's Wonderlands leans a little harder on reads, though the gap is small.
The Binding of Isaac: Afterbirth+
Enemies are random or scripted, never adaptive
Tiny Tina's Wonderlands
Scripted fantasy enemies, no reads
The Binding of Isaac: Afterbirth+ leans a little harder on variance, though the gap is small.
The Binding of Isaac: Afterbirth+
Item pools, room layouts and pickups define each run
Tiny Tina's Wonderlands
Loot rolls and Chaos Chamber RNG
Tiny Tina's Wonderlands leans a little harder on optimization, though the gap is small.
The Binding of Isaac: Afterbirth+
Encyclopedic item synergy knowledge converts variance into wins
Tiny Tina's Wonderlands
Dual classes and spell builds deep
A matching score does not mean a matching test. Two games can both sit at 10 on execution and demand completely different things of you - which is why the reasoning above matters more than the number beside it.