head to head
Neither is simply harder - they are hard in different places. DOOM (2016) demands more optimization; ISS Pro Evolution 2 demands more reads.

Execution · Pure Mechanics
Push-forward arena FPS where movement and aim are the whole game.

Execution · Pure Mechanics
Classic football execution - touch, timing and finishing - with human mind-games on top.
DOOM (2016) leans Execution (Pure Mechanics); ISS Pro Evolution 2 leans Execution (Pure Mechanics).
DOOM (2016) leans a little harder on execution, though the gap is small.
DOOM (2016)
Aim, movement, glory-kill timing all peak.
ISS Pro Evolution 2
First-touch control, through-ball timing and finishing decide matches
ISS Pro Evolution 2 leans clearly harder on reads.
DOOM (2016)
Demons scripted attack patterns.
ISS Pro Evolution 2
Versus humans, baiting tackles and disguising passes matters
ISS Pro Evolution 2 leans a little harder on variance, though the gap is small.
DOOM (2016)
Minimal encounter randomness.
ISS Pro Evolution 2
Slight bounce and keeper randomness within a deterministic sim
DOOM (2016) leans clearly harder on optimization.
DOOM (2016)
Rune and weapon mod picks meaningful.
ISS Pro Evolution 2
Formation and player-role knowledge gives a modest edge
A matching score does not mean a matching test. Two games can both sit at 10 on execution and demand completely different things of you - which is why the reasoning above matters more than the number beside it.