head to head
Fallout: New Vegas asks more than Plague Inc., and the gap is execution.

Optimization · Pure Optimization
A faction-driven RPG-shooter where build and route planning shape every ending.

Optimization · Pure Optimization
Strategy sim about evolving a pathogen to outpace the world's cure effort.
Fallout: New Vegas leans Optimization (Pure Optimization); Plague Inc. leans Optimization (Pure Optimization).
Fallout: New Vegas leans clearly harder on execution.
Fallout: New Vegas
Shooter inputs with VATS assist
Plague Inc.
Tapping menus only
Fallout: New Vegas leans a little harder on reads, though the gap is small.
Fallout: New Vegas
Scripted factions and enemies
Plague Inc.
World response is algorithmic, not adaptive to you
Plague Inc. leans a little harder on variance, though the gap is small.
Fallout: New Vegas
Some loot and crit RNG
Plague Inc.
Spread events and cure pace fluctuate
Same score on optimization - which means the number cannot separate them. The difference is in what each one asks of you.
Fallout: New Vegas
Faction routing, perks, builds heavily rewarded
Plague Inc.
Evolution-point timing strategies are largely solved
A matching score does not mean a matching test. Two games can both sit at 10 on execution and demand completely different things of you - which is why the reasoning above matters more than the number beside it.