head to head
Neither is simply harder - they are hard in different places. Plague Inc. demands more variance; Portal demands more execution.

Optimization · Pure Optimization
Strategy sim about evolving a pathogen to outpace the world's cure effort.

Optimization · Pure Optimization
The portal-gun puzzle game whose solutions are everything.
Plague Inc. leans Optimization (Pure Optimization); Portal leans Optimization (Pure Optimization).
Portal leans clearly harder on execution.
Plague Inc.
Tapping menus only
Portal
Portal placement timing modest.
Same score on reads - which means the number cannot separate them. The difference is in what each one asks of you.
Plague Inc.
World response is algorithmic, not adaptive to you
Portal
No adversary modeling player.
Plague Inc. leans clearly harder on variance.
Plague Inc.
Spread events and cure pace fluctuate
Portal
Deterministic chambers; no randomness.
Same score on optimization - which means the number cannot separate them. The difference is in what each one asks of you.
Plague Inc.
Evolution-point timing strategies are largely solved
Portal
Pure puzzle-solving optimization.
A matching score does not mean a matching test. Two games can both sit at 10 on execution and demand completely different things of you - which is why the reasoning above matters more than the number beside it.