head to head
Neither is meaningfully harder - they pose close to the same test. The widest gap is execution, and it is a single point.

Execution · Twitch Chaos
Twin-stick dodging layered on roguelike build decisions under procedural RNG.

Execution · Twitch Chaos
Twin-stick roguelike where a crying child fights basement horrors with random unholy upgrades.
Full Mojo Rampage leans Execution (Twitch Chaos); The Binding of Isaac leans Execution (Twitch Chaos).
The Binding of Isaac leans a little harder on execution, though the gap is small.
Full Mojo Rampage
Twin-stick dodging and aiming carry every fight
The Binding of Isaac
Twin-stick dodging through bullet-dense rooms
Same score on reads - which means the number cannot separate them. The difference is in what each one asks of you.
Full Mojo Rampage
Enemies are scripted swarms, not adaptive minds
The Binding of Isaac
Enemies follow fixed or random patterns
The Binding of Isaac leans a little harder on variance, though the gap is small.
Full Mojo Rampage
Procedural levels and random pin rolls shape runs
The Binding of Isaac
Item and room RNG defines every run
Same score on optimization - which means the number cannot separate them. The difference is in what each one asks of you.
Full Mojo Rampage
Loadout and blessing choices compound across a run
The Binding of Isaac
Item synergy knowledge converts luck into wins
A matching score does not mean a matching test. Two games can both sit at 10 on execution and demand completely different things of you - which is why the reasoning above matters more than the number beside it.