head to head
Neither is simply harder - they are hard in different places. Grand Theft Auto V demands more reads; Ratchet & Clank Future: Tools of Destruction demands more optimization.

Execution · Practiced Mastery
Sandbox crime playground spanning shooting, driving, and a persistent online economy.

Optimization · Practiced Mastery
The PS3 debut of Ratchet & Clank, mixing exotic weapons with an upgrade-driven adventure.
Grand Theft Auto V leans Execution (Practiced Mastery); Ratchet & Clank Future: Tools of Destruction leans Optimization (Practiced Mastery).
Same score on execution - which means the number cannot separate them. The difference is in what each one asks of you.
Grand Theft Auto V
Driving and shooting demand decent inputs.
Ratchet & Clank Future: Tools of Destruction
Third-person shooting and platforming, moderately demanding
Grand Theft Auto V leans clearly harder on reads.
Grand Theft Auto V
Online PvP exists but mostly gear/positioning, not modeling.
Ratchet & Clank Future: Tools of Destruction
Scripted enemy waves
Grand Theft Auto V leans a little harder on variance, though the gap is small.
Grand Theft Auto V
Some mission and lobby randomness.
Ratchet & Clank Future: Tools of Destruction
Deterministic encounters
Ratchet & Clank Future: Tools of Destruction leans clearly harder on optimization.
Grand Theft Auto V
Heists, money loops, builds learnable.
Ratchet & Clank Future: Tools of Destruction
Weapon levelling economy and upgrade pathing
A matching score does not mean a matching test. Two games can both sit at 10 on execution and demand completely different things of you - which is why the reasoning above matters more than the number beside it.