head to head
Neither is simply harder - they are hard in different places. Hand Simulator demands more variance; Super Mario Odyssey demands more optimization.

Execution · Pure Mechanics
A dexterity gag - fighting intentionally terrible physics controls to do simple tasks.

Execution · Pure Mechanics
A 3D platformer whose joy lives in tight movement and capture-driven traversal.
Hand Simulator leans Execution (Pure Mechanics); Super Mario Odyssey leans Execution (Pure Mechanics).
Super Mario Odyssey leans clearly harder on execution.
Hand Simulator
Wrestling deliberately awkward finger physics IS the game
Super Mario Odyssey
Precise platforming and capture-move tech ceiling.
Hand Simulator leans a little harder on reads, though the gap is small.
Hand Simulator
Multiplayer chaos is physics comedy, not prediction
Super Mario Odyssey
No adaptive opponents whatsoever.
Hand Simulator leans clearly harder on variance.
Hand Simulator
Physics jank makes outcomes wobbly by design
Super Mario Odyssey
Almost no randomness in level design.
Super Mario Odyssey leans clearly harder on optimization.
Hand Simulator
Little system depth beyond learning the controls
Super Mario Odyssey
Moon routes and movement tech learnable.
A matching score does not mean a matching test. Two games can both sit at 10 on execution and demand completely different things of you - which is why the reasoning above matters more than the number beside it.