head to head
Neither is meaningfully harder - they pose close to the same test. The widest gap is execution, and it is a single point.

Execution · Grand Arena
Asymmetric FPS-RTS hybrid where aliens and marines fight under live human commanders.

Execution · Grand Arena
A third-person MOBA where skillshot aim meets MOBA mind games.
Natural Selection 2 leans Execution (Grand Arena); Smite leans Execution (Grand Arena).
Natural Selection 2 leans a little harder on execution, though the gap is small.
Natural Selection 2
Skulk movement and marine aim have steep ceilings
Smite
Third-person skillshots raise the aim floor.
Smite leans a little harder on reads, though the gap is small.
Natural Selection 2
Human commanders mind-game tech and map control
Smite
Jungle invades and ganks require opponent modeling.
Smite leans a little harder on variance, though the gap is small.
Natural Selection 2
Symmetric maps, little randomness
Smite
Buff timers and minor RNG only.
Smite leans a little harder on optimization, though the gap is small.
Natural Selection 2
Tech trees, res flow, and lifeform timings
Smite
Builds, relics, and rotations are theorycrafted.
A matching score does not mean a matching test. Two games can both sit at 10 on execution and demand completely different things of you - which is why the reasoning above matters more than the number beside it.