head to head
Neither is simply harder - they are hard in different places. Portal 2 demands more execution; Sanitarium demands more variance.

Optimization · Pure Optimization
A first-person puzzle game where seeing the solution is the whole skill.

Optimization · Pure Optimization
A classic psychological adventure where an amnesiac navigates surreal delusions to recover his identity.
Portal 2 leans Optimization (Pure Optimization); Sanitarium leans Optimization (Pure Optimization).
Portal 2 leans clearly harder on execution.
Portal 2
Portal placement requires some precision but timing is lenient.
Sanitarium
Point-and-click navigation requires no dexterity
Same score on reads - which means the number cannot separate them. The difference is in what each one asks of you.
Portal 2
No opponent; puzzles are static.
Sanitarium
No opponents; the delusions follow a fixed narrative
Sanitarium leans clearly harder on variance.
Portal 2
Puzzles are deterministic with no randomness.
Sanitarium
Surreal puzzle logic is unknown until reasoned out
Portal 2 leans clearly harder on optimization.
Portal 2
Solving the puzzle's logic IS the entire game.
Sanitarium
Every chapter is a deterministic puzzle to solve
A matching score does not mean a matching test. Two games can both sit at 10 on execution and demand completely different things of you - which is why the reasoning above matters more than the number beside it.