head to head
Neither is simply harder - they are hard in different places. Portal demands more execution; Sanitarium demands more variance.

Optimization · Pure Optimization
The portal-gun puzzle game whose solutions are everything.

Optimization · Pure Optimization
A classic psychological adventure where an amnesiac navigates surreal delusions to recover his identity.
Portal leans Optimization (Pure Optimization); Sanitarium leans Optimization (Pure Optimization).
Portal leans clearly harder on execution.
Portal
Portal placement timing modest.
Sanitarium
Point-and-click navigation requires no dexterity
Same score on reads - which means the number cannot separate them. The difference is in what each one asks of you.
Portal
No adversary modeling player.
Sanitarium
No opponents; the delusions follow a fixed narrative
Sanitarium leans clearly harder on variance.
Portal
Deterministic chambers; no randomness.
Sanitarium
Surreal puzzle logic is unknown until reasoned out
Portal leans a little harder on optimization, though the gap is small.
Portal
Pure puzzle-solving optimization.
Sanitarium
Every chapter is a deterministic puzzle to solve
A matching score does not mean a matching test. Two games can both sit at 10 on execution and demand completely different things of you - which is why the reasoning above matters more than the number beside it.