head to head
Neither is simply harder - they are hard in different places. Portal demands more execution; Vampire Survivors demands more variance.

Optimization · Pure Optimization
The portal-gun puzzle game whose solutions are everything.

Optimization · Pure Optimization
An auto-attacker where picking the right weapon evolutions wins by itself.
Portal leans Optimization (Pure Optimization); Vampire Survivors leans Optimization (Pure Optimization).
Portal leans clearly harder on execution.
Portal
Portal placement timing modest.
Vampire Survivors
Movement is trivial; no aim or precision required.
Same score on reads - which means the number cannot separate them. The difference is in what each one asks of you.
Portal
No adversary modeling player.
Vampire Survivors
Enemies follow fixed spawn scripts; no adaptive opponent.
Vampire Survivors leans clearly harder on variance.
Portal
Deterministic chambers; no randomness.
Vampire Survivors
Level-up offerings and pickup drops are randomized.
Vampire Survivors leans a little harder on optimization, though the gap is small.
Portal
Pure puzzle-solving optimization.
Vampire Survivors
Evolution paths and weapon combinations fully solve the run.
A matching score does not mean a matching test. Two games can both sit at 10 on execution and demand completely different things of you - which is why the reasoning above matters more than the number beside it.