head to head
Neither is meaningfully harder - they pose close to the same test. The widest gap is execution, and it is a single point.

Execution · Twitch Chaos
An open-world survival shooter set in a hostile irradiated Zone full of anomalies and scarce supplies.

Execution · Twitch Chaos
Dodging bullets while leveraging encyclopedic item knowledge against heavy run RNG.
S.T.A.L.K.E.R. 2: Heart of Chornobyl leans Execution (Twitch Chaos); The Binding of Isaac: Repentance leans Execution (Twitch Chaos).
The Binding of Isaac: Repentance leans a little harder on execution, though the gap is small.
S.T.A.L.K.E.R. 2: Heart of Chornobyl
Lethal gunfights with recoil, bleed, and ballistics punish sloppy aim
The Binding of Isaac: Repentance
Dodging dense bullet patterns while aiming is constant pressure
S.T.A.L.K.E.R. 2: Heart of Chornobyl leans a little harder on reads, though the gap is small.
S.T.A.L.K.E.R. 2: Heart of Chornobyl
A-Life NPCs roam but never model the player adaptively
The Binding of Isaac: Repentance
Enemies are random or scripted, never modelling you
The Binding of Isaac: Repentance leans a little harder on variance, though the gap is small.
S.T.A.L.K.E.R. 2: Heart of Chornobyl
Anomalies, emissions, stash rolls, and unknown Zone layouts hide information
The Binding of Isaac: Repentance
Item pools and room rolls reshape every run
The Binding of Isaac: Repentance leans a little harder on optimization, though the gap is small.
S.T.A.L.K.E.R. 2: Heart of Chornobyl
Artifact hunting, gear upkeep economy, and routing through the Zone
The Binding of Isaac: Repentance
Knowing hundreds of item synergies converts RNG into wins
A matching score does not mean a matching test. Two games can both sit at 10 on execution and demand completely different things of you - which is why the reasoning above matters more than the number beside it.
full breakdown
S.T.A.L.K.E.R. 2: Heart of Chornobyl →
full breakdown
The Binding of Isaac: Repentance →