head to head
Neither is simply harder - they are hard in different places. Medal of Honor demands more reads; Super Mario Odyssey demands more execution.

Execution · Pure Mechanics
Modern-military shooting execution with a light multiplayer prediction layer.

Execution · Pure Mechanics
A 3D platformer whose joy lives in tight movement and capture-driven traversal.
Medal of Honor leans Execution (Pure Mechanics); Super Mario Odyssey leans Execution (Pure Mechanics).
Super Mario Odyssey leans clearly harder on execution.
Medal of Honor
Aimbot trivialises both scripted campaign and multiplayer firefights
Super Mario Odyssey
Precise platforming and capture-move tech ceiling.
Medal of Honor leans clearly harder on reads.
Medal of Honor
Human multiplayer lobbies add modest prediction
Super Mario Odyssey
No adaptive opponents whatsoever.
Medal of Honor leans a little harder on variance, though the gap is small.
Medal of Honor
Scripted ambushes are unknown only on first contact
Super Mario Odyssey
Almost no randomness in level design.
Super Mario Odyssey leans clearly harder on optimization.
Medal of Honor
Map and loadout knowledge add a light planning layer
Super Mario Odyssey
Moon routes and movement tech learnable.
A matching score does not mean a matching test. Two games can both sit at 10 on execution and demand completely different things of you - which is why the reasoning above matters more than the number beside it.